… cells, the treatment with A + N stimulated in p53-dependent … relatively low rate of apoptosis
of A549 cells exposed to A + N. … Hence, we selected the melanoma cell line A375, which is …

… -2 OS osteosarcoma and A375 melanoma cell lines. Interestingly, … A375 cells were very
sensitive to camptothecin and we had … of p53-dependent TREM2 induction in non-myeloid cells. …

… p53 is known to be upregulated by camptothecin (CPT), a DNA topoisomerase I inhibitor,
and CPT has been shown to induce both p53-dependent and p53-independent cell death [34]. …

… 1 (CHK1) in response to camptothecin treatment in LNCaP cells.11 Importantly, p53 …
after UV irradiation in MCF7 cells.6 HIPK2 and p53 cooperated in the activation of p53-dependent …

… DNA damage that initiates p53-dependent apoptosis, resulting in cancer cell death [17,50]…
treatment of a wide range of solid tumors [51]. However, an important issue is that cancer cells …

… via p21 in a p53-dependent fashion, and induced caspase mediated apoptosis likely via
inversely … for DEA’s potentiality in the therapy of metastatic melanomas. Since DEA is the major …

… fibroblasts (MEFs) were treated with doxorubicin (Dox) and camptothecin (CPT), and then …
the weakly and highly metastatic human melanoma cell lines SK-MEL-28 (melanoma) and SK-…

… cycle with the aid of p21, an important downstream protein of p53-dependent trans-activation.
On the one hand, p21 binds and inactivates cyclin D/Cdk4, 6 and cyclin E/Cdk2 complexes…

… U2OS cells and treated cells with or without camptothecin (Cpt… melanoma cell line A375 and
the pancreatic carcinoma cell … in DBD of p53 promotes p53-dependent PD-1 expression, we …

… cell cycle phases and following treatment with camptothecin (… mRNA occurs in a p53-dependent
manner. Because several … and enhanced p21 protein levels in melanoma cells and (ii) …